Study from the NRNU MEPhI Laboratory of Nano-Bioengineering concerning the development of new types of quantum dots for medical applications is published in the JETP Letters, a top-rated Russian journal

Pisma v ZhETF, the original Russian version of the JETP Letters, has published a study by P. A. Linkov, K. V., Vokhmintcev, and P. S. Samokhvalov of the Nanochemistry Group, Laboratory of Nano-Bioengineering (LNBE); Prof. I. R. Nabiev, the leading scientist of LNBE; and their French colleagues M. Laronze-Cochard and J. Sapi of the University of Reims, entitled Effect of Semiconductor Quantum Dot Shell Structure on Fluorescence Quenching by an Acridine Ligand, with the English version to appear in six weeks.

This study is part of LNBE's large-scale research in the priority field of medicine dealing with designing nano-sized fluorescent probes for targeted delivery of antitumor drugs to cancer cells. The fluorescence is used here for real-time monitoring and control of the delivery. This is especially important in preclinical trials as a means to clearly determine how the new delivery system will behave in real life. In the probes designed in LNBE, core/shell quantum dots (QDs), semiconductor nanocrystals with bright, stable photoluminescence, serve as the optical labels.

The problem is, the QD luminescence is strongly quenched due to photoinduced charge transfer from the QD to the organic anticancer agent. The authors have found that this problem can be solved by using a multicomponent shell instead of the purely ZnS oneroutinely used to coat the QD's CdSe core. The LNBE Nanochemistry Group has been designing QDs of precisely this type for several years. In the given case, the ZnS/CdS/ZnS shell structure has proved to be optimal. The study has shown that the bound acridine antitumor drug only weakly quenches the photoluminescence of nanoprobes based on CdSe/ZnS/CdS/ZnS QDs, as opposed to the structures based on QDs with the classical one-component shell. The results of the study give grounds to believe that the nanoprobes designed can penetrate into live cells and intercellular compartments, with a high fluorescence quantum yield preserved.

JETP Letters is one of the most cited Russian journals publishing first-hand reports on studies in various fields of physics. Its impact factor in the international rating is 1.235, and it falls into Q2 of journals in the Physics and Astronomy (miscellaneous), group.

Originally Russian only, the journal has also been coming out in English for almost two decades.

Contacts:

Pavel A. Linkov, junior researcher (valinkov@gmail.com)

Pavel S. Samokhvalov, PhD, senior researcher (p.samokhvalov@gmail.com)

Maria G. Korenkova, director of external relations (MGKorenkova@mephi.ru)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation
http://www.lnbe.mephi.ru/en

 
 
 
© 2012 Laboratory of Nano-BioEngineering