Laboratory of Nano-Bioengineering's study on early clinical diagnosis of micrometastases and disseminated tumor cells accepted by the top-rated Nature: Scientific Reports

A recent study by Laboratory of Nano-Bioengineering (LNBE) researchers and their German and French colleagues tackling early cancer diagnosis (F. Ramos-Gomes, J. Bode, A. Sukhanova, S. V. Bozrova, M. Saccomano, M. Mitkovski, J. E. Krueger, Wa. Stuehmer, A. K. Wege, P. S. Samokhvalov, D. Baty, P. Chames, I. Nabiev, and F. Alves. Single- and two-photon imaging of human micrometastases and disseminated tumour cells with conjugates of nanobodies and quantum dots) has been accepted by the Nature: Scientific Reports, a top-rated international journal.


The study continues a series of LNBE's developments in the field of diagnostic nanoprobes based on fluorescent quantum dots and ultrasmall capture molecules, single-domain antibodies or so-called nano-antibodies. The authors made use of the advantage offered by an extremely large two-photon absorption cross-section, a unique property of quantum dots. The use of two-photon excitation of fluorescent quantum dots in the infrared region of the optical spectrum, combined with laser scanning confocal microscopy, adds to the sensitivity of detection of microscopic tumor foci deep in tissues and tumor cells disseminated over the body. Model experiments on mice with xenografted human tumors have confirmed the feasibility of reliable detection of both micrometastases and single tumor cells carried by the bloodstream. The application of this approach to practice will ensure not only cancer diagnosis at the earliest stages, but also tracing tumor cells and micrometastases left after a treatment course in an individual-oriented manner, thus estimating the risk of tumor relapse. This, in turn, will raise the chances for the ultimate success of treatment.

The Scientific Reports is a Nature Publishing Group journal; it publishes original research in all areas of the natural and clinical sciences, and it has been included in the JCR's first quartile of interdisciplinary journals for five years in a row. It is a special pleasure to note that the manuscript was accepted for publication without reviewers' or editors' criticisms or corrections.


Svetlana V. Bozrova, engineer (

Pavel S. Samokhvalov, PhD, senior researcher (

Maria G. Korenkova, director of external relations (

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
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