Seminars of the Laboratories of Nano-Bioengineering (LNBE) and Hybrid Photonic Nanomaterials (LPNM) of NRNU MEPhI: Results of ongoing projects

Feb 20 and 22 the cluster of two NRNU MEPhI international laboratories, the Laboratory of Nano-Bioengineering (LNBE) and the Laboratory of Hybrid Photonic Nanomaterials (LPNM), held seminars to discuss the interim results and prospects of research projects currently underway in the laboratories.

Professor Igor Nabiev, Leading Scientist of LNBE, presented a review of ongoing projects, under the title "Quo vadis?". The cluster of international laboratories is carrying out about a dozen projects in the framework of Federal Target Programs and a State Contract of the RF Ministry of Education and Science and the RF Ministry of Health, as well as those supported by the Russian Science Foundation, Russian Foundation for Basic Research, and EU's Horizon-2020 ERA-NET. In addition, research work of LPNM (Leading Scientist, Prof. Yuriy Rakovich) is supported by the RF Grant for Supporting Research under the Direction of World's Leading Scientists (MEGA-Grant). The past year's results show that the projects go successfully; two projects, Plasmon-Bio and Crystal-Bio, have alredy come up with  prototype devices for multiplexed pathogen detection and medical diagnosis.

Pavel Samokhvalov, PhD, the head of the LNBE Nanochemistry Group, presented the project on Integrated Computational Engineering, Characterization and Validation of Semiconductor Colloidal Nanocrystals with Advanced Properties aimed at designing a novel type of quantum dots with high quantum yield and stability in biological media. Specifically, multishell quantum dots with improved charge confinement have been engineered, and a robot for automated layering of the multilayered shells has been built up.

Pavel Linkov of the LNBE Nanochemistry Group made a statement on the Synthesis and Physicochemical Properties of Highly Luminescent Semiconductor Nanoparticles for Biomedical Applications. This research, which is a joint project with the University of Reims, France, is aimed at the development of multifunctional probes for diagnosis and treatment of cancer (in the latter case, the objective is targeted drug delivery to cancer cell nuclei). The results of this research have been reported in four papers, and the speaker himself is finishing his PhD project.

Galina Nifontova, PhD, of the LNBE Nanomedicine Group summarized the preliminary results of the project Multifunctional Stimulus-Sensitive Microcapsules and Nanocrystals for Early Diagnosis and Efficacious Treatment of Lung and Breast Cancers. This is another line of research in LNBE that deals with targeted delivery of diagnostic fluorescent labels and drugs to a malignant tumor. Preclinical trials of the delivery systems developed are scheduled to the last stages of the project. The results obtained to date are described in six papers, four of them published and two accepted for publication.

Svetlana Bozrova, of the same research group, told about the progress of the project on the Basic Issues of Designing Biosensors Based on Nontoxic Colloidal Nanocrystals and Their Interaction with Biological Systems. Here, special effort is made to estimate the toxicity of the diagnostic nanolabels and analyze its mechanisms in order to develop nontoxic diagnostic probes for in vivo uses. Three papers on this subject have been published or accepted by top-rated international journals, including Nature: Scientific Reports and Nanoscale Research Letters, in the past year.

Professor Yuriy Rakovich, Leading Scientist of LPNM, presented the project Linear and Nonlinear Nanoscale Optical Effects for Designing Next-Generation Biosensors. Prof. Rakovich summarized the developments of new hybrid nanomaterials intended for medical diagnostic applications employing biosensing. These studies are carried out in collaboration with the Materials Physics Center (joint CSIC-UPV/EHU center, Spain), where two young researchers from LPNM of NRNU MEPhI had on-job training recently. The results of these studies have already been reported in four publications (with several more papers just been submitted); they have been widely presented at the 2nd International Symposium on Physics, Engineering and Technologies for Biomedicine; in addition, a patent application has been submitted.

The following two statements dealt with individual lines of research in this field.

Viktor Krivenkov told about research in biexciton states of quantum dots. Biexciton states are of considerable practical interest since they ensure a high quantum efficiency of light-to-electricity conversion triggered in a semiconductor absorbing light. The obtainment and detection of biexciton states entail a number of problems whose possible solutions were discussed in the statement.

Dmitriy Dovzhenko presented the development of structures based on porous silicon intended for obtaining light–matter hybrid states in the strong coupling mode. The use of the strong coupling effect opens up wide prospects in photonics, quantum communication, quantum optics, as well as biology and medicine.

Alyona Kosmyntseva, a postgraduate student doing research at LPNM, reported on the Study of Polymer–Nanoparticle Interaction, summarizing preliminary results of one more LPNM research area related to medicine, detection and analysis of the binding of quantum dots with DNA and estimation of how the nanoparticles affect the structure of biopolymers under different conditions.

Contacts:

Maria G. Korenkova, director of external relations (MGKorenkova@mephi.ru)
Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation
http://www.lnbe.mephi.ru/en

Alexandra V. Korenkova, research engineer (alexandrav.korenkova@gmail.com)
Laboratory of Hybrid Photonic Nanomaterials, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation
http://lpnm.mephi.ru/index.php/ru/

 
 
 
© 2012 Laboratory of Nano-BioEngineering