Members of the NRNU MEPhI Laboratory of Nano-Bioengineering got a patent on a method for synthesizing ultrasmall (even smaller than usual) photoluminescent nanoparticles

The RF Intellectual Property Agency (Rospatent) has made a decision on issuing a patent on the invention made by members of the Laboratory of Nano-Bioengineering (LNBE) of NRNU MEPhI, Pavel Samokhvalov, PhD, deputy head of the laboratory, and Pavel Linkov, junior researcher, entitled A Method of Colloidal Synthesis of Ultrasmall Photoluminescent Core/Shell Nanoparticles (application no. 2016151342 of 27 Dec 2016).


This invention solves the problem of obtaining bright photoluminescent nanoparticles of ultrasmall size that are necessary for engineering compact diagnostic labels capable of penetrating into cells and even cell nuclei. The innovative solution includes the arrest of the synthesis of nanoparticle cores at early growth stages by drastic cooling of the reaction mixture from temperatures higher than 200°C within less than 5 seconds, as well as the use of exclusion chromatography for fine purification of the nanocrystals from admixtures and byproducts.

The invention makes it possible to obtain quantum dot cores less than 2 nm in diameter with reproducible optical parameters and physical sizes to be used in advanced biomedical diagnostic and optoelectronic systems based on photoluminescent nanoparticles.

The invention was made in the course of the project under State Contract no. 624.2014/K "Colloidal fluorescent nanocrystals, quantum dots and quantum rods, for multiphoton spectroscopy, microscopy, and imaging of tumors in situ".


Pavel A. Linkov, junior researcher (

Maria G. Korenkova, director of external relations (

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

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