MULTIFUNCTIONAL STIMULUS-SENSITIVE MICROCAPSULES AND NANOCRYSTALS FOR EARLY DIAGNOSIS AND EFFICACIOUS TREATMENT OF LUNG AND BREAST CANCERS (State Contract no. 16.1034.2017/PCh)

In the course of applied research on Multifunctional Stimulus-Sensitive Microcapsules and Nanocrystals for Early Diagnosis and Efficacious Treatment of Lung and Breast Cancers (State Contract no. 16.1034.2017/PCh, Grant Agreement of May 31, 2017), methods for synthesis of the low-toxic CuInS2/ZnS and CuInS2-xSex/ZnS fluorescent nanocrystals (quantum dots, QDs) intensely fluorescing in the visible and near IR regions have been developed.The use of fluorescence in the wavelength region of 700–900 nm, also referred to as the transparency window of biological tissues and fluids, makes it possible to detect fluorescent signals from deep areas of the sample. Therefore, incorporation of CuInS2/ZnS QDs into the walls of stimulus-sensitive microcapsules will allow their specific detection and the imaging of their targeted transport in vivo. The scheme of manufacturing of the nanotechnological system and the methodical guidelines for its future use in medical diagnosis and targeted drug delivery have been prepared. In addition to the basic scheme, variants of further extension of applications of the nanotechnological system designed have been proposed.

Contacts:

Principal Investigator of the project:
Prof. Igor R. Nabiev, PhD, DSc, leading scientist of LNBE (igor.nabiev@gmail.com)

Maria G. Korenkova, LNBE director of external relations (MGKorenkova@mephi.ru)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation
http://www.lnbe.mephi.ru/en

 
 
 
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