New invention in cancer diagnosis from the Laboratory of Nano-Bioengineering

The RF Intellectual Property Agency (Rospatent) has made a decision on issuing a patent on A Method of Fabrication of an Analytical Test System Based on Suspension Microarrays for Detecting Disease Markers developed by A. V. Sukhanova, R. S. Bilan, V. V. Terekhin, and I. R. Nabiev.

The suspension microarrays are polymer microbeads with capture molecules (e.g., antibodies) on their surface that are optically encoded with semiconductor fluorescent nanocrystals (quantum dots). Layers of quantum dots fluorescing in different spectral regions are separated from one another with polyelectrolyte layers. A practically unlimited number of various combinations of differently colored quantum dots makes it possible to form a unique code for each biomarker recognized by the detection molecules.

The microarrays developed in the laboratory allow simultaneous quantitative detection of markers of various diseases with a high sensitivity. The invention is supposed to be primarily used for detection of cancer markers, including carcinoembryonic antigen and specific markers of breast, ovarian, and cervical cancers.

Of special importance is that the fluorescent signal is read by means of flow cytometry with the use of state-of-the-art instruments which is routine in clinical practice.

Implementation of this invention into practice will improve cancer diagnosis, especially at early stages when surgical removal of the tumor is likely to result in full recovery.


Maria G. Korenkova, LNBE director of external relations (

Regina S. Bilan, engineer, LNBE (

Prof. Igor R. Nabiev, PhD, DSc, leading scientist, LNBE (

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

© 2012 Laboratory of Nano-BioEngineering