A paper from the Laboratory of Nano-Bioengineering on a novel method of 3D analysis of materials published in the Ultramicroscopy, which ranks first among 133 international journals in the Instrumentation subject category

Researchers of the Laboratory of Nano-Bioengineering (LNBE) of NRNU MEPhI in collaboration with their Russian and foreign colleagues has developed a novel approach to nanoscale multiparametric 3D analysis of various materials and designed a laboratory setup to implement this approach. The results of this work have just been published (Mochalov, K.E., Chistyakov, A.A., Solvyeva, D.O., Mezin, A.V., Oleinikov, V.A., Molinari, M., Agapov, I.I., Nabiev, I., Efimov, A.E. (2017) An instrumental approach to combining confocal microspectroscopy and 3D scanning probe nanotomography. Ultramicroscopy, 182, 118–123).

The new technique and instrumentation extends the possibilities of correlative microscopy, an approach to nanoscale analysis of topography and various physical properties (elasticity, conductivity, etc.) in a single region of a sample that has been intensely developed in the past decade. The design presented by the authors makes it possible to carry out the scanning probe microscopy and confocal optical microspectroscopy analyses and nanotomography of a sample by means of a single laboratory setup. This allows a researcher to obtain 3D images of nanosized areas of the material and simultaneously record the spatial distributions of not only mechanical and electrical (as in previous developments), but also the optical and chemical characteristics in the same areas.

The new approach can be used for multiparametric 3D examination of artificial nanostructured materials (such as polymer matrices doped with nanoparticles), as well as biological samples. This offers greater possibilities for both material science and biomedicine. The authors have already successfully tested the new setup on fluorescent polymer microbeads doped with magnetic nanoparticles, microstructures employed in multiparametric immunodiagnostics.

The Ultramicroscopy is a highly rated journal published by Elsevier BV (Netherlands) which is included in the first quartiles (Q1) in three subject categories:

-          Atomic and Molecular Physics and Optics,

-          Electronic, Optic and Magnetic Materials, and

-          Instrumentation.

The Ultramicroscopy ranks first among the 133 international journals that publish papers in the Instrumentation subject category and specializes in presenting advances in designing research equipment and instrumentation, as well as methods and theories pertaining to all aspects of microscopic imaging, diffraction, and spectroscopy as applied to both physics and life sciences.


Konstantin E. Mochalov, Ph.D., senior research assistant (mochalov@mail.ru)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation


© 2012 Laboratory of Nano-BioEngineering