A paper on an LNBE's recent development in multiplexed detection in diagnosis accepted for publication by the ChemPhysChem, a top-rated international journal

The ChemPhysChem has accepted for publication the paper on Engineering of optically encoded microbeads with FRET-free spatially separated quantum dot layers for multiplexed assays by Regina Bilan, Viktor Krivenkov, Pavel Samokvalov, Igor Nabiev, and Alyona Sukhanova describing a recent development by researchers of LNBE and their colleagues in the field of multiplexed analysis in diagnosis.

This study is part of LNBE's research and developments in suspension diagnostic systems based on polymer microbeads optically encoded with quantum dots (QDs). In the given case, optical coding is performed by successively applying oppositely charged polyelectrolytes and water-soluble QDs. This technology yields microbeads coated with multilayered shell consisting of several layers of QDs separated from one another by polyelectrolyte layers.

The authors have demonstrated that the resultant optical code of the microbeads depends not only on the quantitative ratio between different QDs included in a microbead, but also on a number of physical and chemical phenomena that occur upon the QD adsorption on the microbead surface, including non-radiative energy transfer between QDs of different colors within the same microbead shell. Analysis of these factors has allowed the authors to develop the concept of engineering spectrally encoded microbeads whose spectral codes are not disturbed by energy transfer between QDs of different colors.

The concept developed can be adapted for designing a practically unlimited number of spectral codes. The microbeads optically encoded with QDs are expected to be used in various fields requiring simultaneous detection of small amounts of different substances in solutions and suspensions, primarily, for detecting multiple disease markers in clinical samples.

The ChemPhysChem is a top-rated international journal published by ChemPubSoc Europe, a joint organization of a number of European chemical societies. Founded as a journal of chemical physics and physical chemistry, the ChemPhysChem is now an interdisciplinary journal whose scope encompasses diverse basic and applied issues of physics, chemistry, biology, and related fields.


Regina S. Bilan, junior researcher, Nanomedicine Group (reginchg@gmail.com)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation


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