A study "Quantum Dot–Based Nanotools for Bioimaging, Diagnostics, and Drug Delivery" from the Laboratory of Nano-Bioengineering of NRNU MEPhI published in the ChemBioChem

The paper Quantum Dot–Based Nanotools for Bioimaging, Diagnostics, and Drug Delivery published by researchers from the Laboratory of Nano-Bioengineering describes recent studies on bioimaging, diagnosis, and targeted drug delivery using nanolabels based on quantum dots.

The nanolabels are conjugates of quantum dots with biomolecules, such as proteins (including antibodies), peptides, nucleic acids, and low-molecular-weight compounds. At present, these nanolabels are most widely used in immunofluorescence assays in cell culture and tissue samples, as well as in vitro ("in a test tube") analysis of specific markers. However, unique photochemical properties of quantum dots make the nanolabels containing them promising for studying the behavior of individual molecules on the surface and inside of live cells.

Owing to their highly bright fluorescence and the possibility of synthesizing nanocrystals fluorescing in the infrared region, these nanolables could be used in in vivo research, in particular, in diagnosis of malignant tumors and analysis of drug distribution in organs and tissues. The paper analyses the most important questions related to these applications of quantum dot–based nanolabels:

-          Is it possible to use these nanolabels in the human body?

-          How toxic the nanolabels are, and in what ways can their toxicity be decreased?

-          What imaging techniques are applicable to these nanolabels?

-          Is it possible to design a "versatile" nanolabel serving for several purposes?

Contact:

Regina Bilan, junior researcher (reginchg@gmail.com)

Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

http://www.lnbe.mephi.ru/en

The journal website and online publication:

http://onlinelibrary.wiley.com/doi/10.1002/cbic.201600357/abstract

 
 
 
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