Multifunctional Nanoprobes for Imaging Tumor Cells and Targeted Delivery of Antitumor Drugs: A new project from LNBE won the competition of the Russian Foundation for Basic Research

The project on Multifunctional Nanoprobes for Imaging Tumor Cells and Targeted Delivery of Antitumor Drugs proposed by the LNBE has received support from the Russian Foundation for Basic Research for the period 2016–2018.

The project is based on an integrated approach to diagnosis and treatment of malignant tumors by means of nanoprobes consisting of three components:

-          a fluorescent semiconductor nanocrystal,

-          a vector for intracellular delivery ensuring transport across the cell membrane, and

-          an antitumor drug.

This approach ensures pinpoint-precise delivery of the drug into a tumor cell due to the active vector molecule. An ultra-small fluorescent quantum dot allows the nanoprobe to be visualized and its movement within the cell to be traced.

The expected output of the project is a next-generation compact multi-purpose nanoprobe intended for targeted intracellular delivery of therapeutic agents whose transport and interaction with a tumor cell can be monitored in the real-time mode with the use of confocal lacer microspectroscopy.

Contact:

Pavel A. Linkov, junior researcher (valinkov@gmail.com)

Laboratory of Nano-Bioengineering,
National Research Nuclear University MEPhI
(Moscow Engineering Physics Institute)
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

http://www.lnbe.mephi.ru/en

 
 
 
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