LNBE's project won the competition of the Federal Target Program "National System of Chemical and Biological Safety of Russia (2015–2020)"

The project on Development of the Theory and Methodology for Engineering of Multiparameter (Multiplexed) Test Systems Based on Immunochips for Detecting and Identifying Biological Pathogens proposed by LNBE has won the project competition of the Ministry of Health of the Russian Federation in the framework of the Federal Target Program "National System of Chemical and Biological Safety of Russia (2015–2020)"

The project goal is to develop the theory and techniques for engineering of suspension diagnostic systems intended for simultaneous detection of antibodies against the pathogens of highly dangerous and socially significant infections in human blood. The diagnostic systems are expected to be used by the National Integration Center for Monitoring of Biological Hazards that is being organized by the RF Ministry of Health. They will also be useful both for population screening in the cases of epidemic threat and for regular mass medical examinations.

The test system will represent sets of polymer microbeads optically encoded with fluorescent semiconductor nanocrystals with different spectral characteristics and carrying deactivated markers of infectious diseases (antigens) on their surface. In the case of a disease, antibodies binding the antigens of the bacteria or viruses that have caused the disease appear in the bloodstream at an early stage of illness. These antibodies will be detected by the fact of their binding with the antigens on the surface of the optically encoded microbeads, and the optical code will serve to identify them as antibodies against a specific virus or bacterium.

The advantage of the diagnostic systems to be developed is that they will allow simultaneous detection of several diseases in a single clinical sample at high sensitivity and specificity. Their use in clinical diagnostics will save much time and reduce the amount of biological material necessary for analysis.

Contact:

Prof. Igor Nabiev, PhD, DSc, leading scientist (igor.nabiev@gmail.com)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

http://www.lnbe.mephi.ru/en

 
 
 
© 2012 Laboratory of Nano-BioEngineering