As many as twelve reports from LNBE are to be presented at the prestigious international conference "Advances in Functional Materials" in the State University of New York at Stony Brook, NY, USA

A prestigious international conference on recent developments in designing and studying new functional materials (Advances in Functional Materials) is to be held at Stony Brook University, NY, USA, in late June to early July 2015.

The list of lecturers at the conference includes two Nobel Prize laureates: Prof. Alan Jay Heeger, a winner of the 2000 Nobel Prize in chemistry "for the discovery and development of conductive polymers," and Prof. Robert Howard Grubbs, a winner of the 2005 Nobel Prize in chemistry "for the development of the metathesis method in organic synthesis."

All LNBE's research groups and main lines of research will be represented at the Advances in Functional Materials conference. Researchers of LNBE will make 10 oral and 2 poster presentations. The two oral presentations will be made by Prof. Igor R. Nabiev, the leading scientist of LNBE.

All reports presented at the conference will be published in the Materials Today: Proceedings, a prestigious Elsevier journal whose specialty is proceedings of conferences on novel materials.

The report on High Quantum Yield of CdSe/ZnS/CdS/ZnS Multishell Quantum Dots Intended for Biosensing and Optoelectronic Applications by Pavel Linkov et al. describes the engineering of core–multishell nanocrystals developed in LNBE. The multilayered shell ensures strong charge confinement and protection from the environment, which has allowed the authors to obtain nanocrystals with a fluorescence quantum yield close to 100%.

The use of these core–multishell nanocrystals for designing highly efficient light-emitting diodes is described in the report on Application of CdSe/ZnS/CdS/ZnS Core–Multishell Quantum Dots to Modern OLED Technology by Sergey Dayneko et al.

The report by Pavel Samokhvalov et al. entitled Simulation of Quantum Dot Growth: Towards Rational Development of Nanomaterials with Predictable Properties describes a mathematical model developed in the LNBE for optimizing the procedures of the chemical synthesis and growth of the multishell to obtain nanocrystals with advanced properties.

Unique structures based on porous silicon have been used in LNBE for engineering a new generation of photonic structures by introducing fluorescent nanocrystals into the pores. The report Porous Silicon Microcavity Modulates the Photoluminescence Spectra of Organic Polymers and Quantum Dots by Dmitriy Dovzhenko et al. describes the possible implications of these structures for optical diagnostic systems, as well as for lasing in hybrid materials of a new type.

The study of Förster resonance energy transfer (FRET) from nanocrystals to photosensitive biological systems is one of the research areas of LNBE. This research is promising in terms of designing biophotonic hybrid photovoltaic devices. The report Two-Photon-Induced Förster Resonance Energy Transfer in a Quantum Dot–Bacteriorhodopsin Hybrid Material by Viktor Krivenkov et al. deals with the use of two-photon excitation of nanocrystals, which allows, first, their selective excitation and, second, efficient use of the IR spectral region in bio-photovoltaics.

Changes in the functional characteristics of biological systems upon interaction with nanostructures have been studied by Konstantin Mochalov et al. (Silver Nanoparticles Strongly Affect the Properties of Bacteriorhodopsin, a Photosensitive Protein of Halobacterium salinarum Purple Membranes). They have shown that silver nanoparticles can suppress the photocycle of bacteriorhodopsin, thereby making it possible to control its biological function.

The development of new instrumental methods for studying nanostructures and components of nanohybrid materials, as well as improvement of the existing ones, is one of the main activities of the Biophysics Group of LNBE. At the conference, it will be represented by the report on Raman and SERS Spectroscopy of D96N Mutant Bacteriorhodopsin by Konstantin Mochalov et al.

Quantum dots contained in nanohybrid materials can reversibly switch between radiative (fluorescence) and nonradiative (FRET) energy transfers in response to changes in the environmental conditions. This property is used in sensors of temperature, pH, and other parameters, especially when real-time monitoring in reaction volumes as small as nano-volumes is required. The development of temperature sensors of this type is described in the report entitled Submicron QDs-Containing Particles as Nano-Thermosensors to be presented by Vladimir Oleinikov, PhD, DSc, the head of the Biophysics Group of LNBE.

Biomedical applications of nanotechnologies constitute the key LNBE's line of research and the main field of developments. The Nanomedicine Group plays the leading role in this field; with all other research groups contributing to it. It is in this area that LNBE is most actively engaged in international collaboration. LNBE biomedical research will be represented by four reports at the conference.

In the first report (Ultra-Small Diagnostic Nanoprobes Based on the Oriented Conjugates of Single-Domain Antibodies and Quantum Dots), Igor Nabiev, the head of LNBE, will present the diagnostic probes developed in the laboratory that consist of single-domain antibodies against cancer biomarkers and nanocrystals. The probes are an order of magnitude smaller than their commercially available analogues and, hence, penetrate much deeper into tissues. In addition, their capture molecules are bound with the nanocrystals in a strictly oriented manner (with all the recognition sites facing outside and not screened by the nanocrystal surface), which increases the probe's sensitivity by more than an order of magnitude.

Combination of the ultrasmall conjugates of single-domain antibodies and nanocrystals with the possibility of multiphoton excitation of nanocrystal fluorescence allows one to get rid of the background autofluorescence of biological tissues by exciting the nanocrystals in the IR spectral region, where the tissue fluorescence is not induced (Highly Oriented Conjugates of Single-Domain Antibodies and Quantum Dots for Multiphoton Imaging of Tumor Biomarkers in situ).

A similar principle is used in the study on Cancer Marker Profiling by Means of Microbead–Quantum Dot Microarrays by Kristina Brazhnik et al., who have designed liquid-state microarrays for simultaneous detection of multiple cancer biomarkers. To date, LNBE has developed such diagnostic systems for detection of two cancer markers; the potential number of simultaneously detectable markers is almost unlimited.

In addition to purely diagnostic purposes, the microarrays based on the conjugates of capture antibodies and nanocrystals can be used for analyzing pathological processes at the cellular level, such as alteration of the protein phosphorylation pattern upon DNA damage. The results of this analysis are described in the report Quantum Dot–Based Microarray for Analysis of Modifications of Cellular Phosphoproteome in Response to DNA Damage.

Research in all the fields represented in the conference reports from LNBE goes on. Some developments have already been patented and are going to be implemented in practice.

Contact:

Prof. Igor Nabiev, PhD, DSc, leading scientist (igor.nabiev@gmail.com)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

http://www.lnbe.mephi.ru/en

 
 
 
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