LNBE wins the competition of applications for research projects under the state contract of the Ministry of Education and Science

The list of winners in the competition of research projects to be implemented under the state contract has been approved by the Commission for the Formation of the State Contract with Higher Education Institutions and Research Institutions of the Ministry of Education and Science of the Russian Federation in the Field of Science (Minutes no. 1 of June 10, 2014). Details of the competition are publicized at http://xn--80aahfgik3be4a.xn--p1ai/news/more/newsId/97 and http://xn--80aahfgik3be4a.xn--p1ai/index/index.

The winning project of LNBE in the field of applied research is entitled Colloid Fluorescent Nanocrystals, Including Quantum Dots and Quantum Rods, for Multiphoton Spectroscopy, Microscopy, and in Situ Imaging of Tumors.

The goals of the project are the development of a new generation of multiphoton fluorescent probes based on semiconductor nanocrystals, including the so-called quantum dots (QDs) and quantum rods (QRs); analysis of the physical, physicochemical, and optical characteristics of these probes; and demonstration of their advantages as diagnostic tools for highly sensitive imaging of cancer markers, as exemplified by human carcinoembryonic antigen (CEA).

The project includes (1) the engineering of multicolor multiphoton fluorescent nanoprobes based on QDs and QRs; (2) detailed study of the physical (size, shape, and degree of crystallinity), physicochemical (stability in water solutions), and optical (quantum yield, one- and multiphoton absorption cross-sections, and dependence of fluorescence intensity on wavelength) characteristics of the probes developed, as well as demonstration of their advantage over the state-of-the-art multiphoton probes based on organic fluorophores in terms of optical parameters; and (3) the demonstration that the novel two-photon nanoprobes are applicable to in situ imaging of the CEA cancer marker in the sections of biopsies of tumor and normal human tissues, as well as confirmation that the novel nanoprobes have advantages over the state-of-the-art two-photon probes based on organic dyes.

Contact:

Prof. Igor Nabiev, PhD, DSc, leading scientist (igor.nabiev@gmail.com)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

http://www.lnbe.mephi.ru/en

 
 
 
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