Practical training of our researchers in Göttingen: Part of the LNBE program for extending international collaboration

In July 2014 two researchers of the Nanomedicine Group, Maria Baryshnikova and Zinaida Sokolova, took a course of practical training in the Translational Oncology Group headed by Prof. Frauke Alves at the Max-Planck Institute of Experimental Medicine, Göttingen, Germany.

Our colleagues mastered methods of immunocytochemical and immunohistochemical staining of tumor cells and tissue sections and used them to test streptavidin–quantum dot conjugates engineered by Regina Grinevich in the Nanomedicine Group of LNBE.

Single-domain antibodies against HER2 tyrosine kinase transmembrane receptor, a well-known cancer marker belonging to the epidermal growth factor receptor family, conjugated with quantum dots were used for immunohistochemical estimation of the HER2 expression rate in sections of tissue biopsies from patients with breast cancer. This approach was demonstrated to be more sensitive and accurate than traditional staining methods using organic fluorophores.


Maria A. Baryshnikova, MD, PhD, engineer (

Zinaida A. Sokolova, MD, PhD, engineer (

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

© 2012 Laboratory of Nano-BioEngineering