A paper from LNBE published in the ACS Nano, a highly rated journal that is a leading periodical in nanoscience and nanotechnology

The ACS Nano has published a paper by LNBE researchers and their colleagues from Ireland, the United Kingdom, Belgium, France, and Germany describing unique nanoprobes for early cancer diagnosis developed by the authors (Rakovich, T.Y., Mahfoud, O.K., Mohamed, B.M., Prina-Mello, A., Crosbie-Staunton, K., Van Den Broeck, T., De Kimpe, L., Sukhanova, A., Baty, D., Rakovich, A., Maier, S.A., Alves, F., Nauwelaers, F., Nabiev, I., Chames, P., Volkov, Y. Highly Sensitive Single Domain Antibody-Quantum Dot Conjugates for Detection of Low Expression Levels of HER2 Biomarker in Lung and Breast Cancer Cells).

In oncology, early diagnosis is of special importance and often crucial for efficacious noninvasive treatment. Therefore, enhancement of the sensitivity and specificity of diagnostic methods is a priority. The use of optical probes based on antibodies against cancer biomarkers is the most efficient strategy in cancer diagnostics to date.

The novel nanoprobes consisting of single-domain antibodies against a cancer biomarker (namely, human epidermal growth factor receptor) and fluorescent nanocrystals (quantum dots) may become a breakthrough in this field. Experiments on lung and breast tumor cell lines, as well as mixed cultures of tumor cells and normal fibroblasts, have demonstrated high sensitivity and specificity of the nanoprobes with respect to the target biomarker. Owing to the small size and bright fluorescence in a narrow spectral band, these nanoprobes allow cancer-specific antigens to be detected much more reliably compared to currently available probes (based on conventional monoclonal antibodies and organic fluorophores).

ACS Nano is one of the world's leading journals publishing the results of studies at the interface of nanotechnology with chemistry, biology, physics, and engineering. With its exceptionally high impact factor of 12.068, the journal ranks ninth among the world's best 214 journals on materials science, ninth among the best 152 journals on chemistry, and fifth among the best 69 journals on nanoscience and nanotechnologies.

The paper is available at http://pubs.acs.org/doi/abs/10.1021/nn500212h.


Prof. Igor Nabiev (igor.nabiev@gmail.com).

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation


© 2012 Laboratory of Nano-BioEngineering