A review from LNBE is announced on the cover of the Nanotechnologies in Russia

The title of the review Interactions of Proteins and Peptides with Nanoparticles: Structural and Functional Issues by researchers of the Nanomedicine Group and Prof. Igor Nabiev, the leading scientist of LNBE, and a figure from this article have been chosen for the cover picture of the ongoing issue of the Rossiiskie Nanotekhnologii / Nanotechnologies in Russia (vol. 8, nos. 11–12).

We congratulate the authors of the study that has gained this distinction and presume that the Editorial Office's choice was mainly determined by the theoretical and applied importance of the subject and comprehensive coverage and summary of the available data.

Indeed, the ever-increasing use of nanoparticles in various areas, including biological research and medicine, has made nanoparticle applications an urgent topic. To our knowledge, the article by our colleagues is the most comprehensive review of literature data on how various types of nanoparticles affect the structure and functions of proteins and peptides

In addition, the authors consider the available data on the pathways for the penetration of nanoparticles into the body, in the cases of both intentional administration as a part of diagnostic or therapeutic drugs and accidental contact with nanoparticles (e.g., when they are present in the environment as industrial pollutants).

The pathologies that may be caused by nanoparticles penetrating into the human body are also discussed.

 

The small size makes nanoparticles a special kind of alien agents because they can penetrate not only through blood–tissue barriers, but also into live cells; this is why it is important to investigate their interaction with enzymes, cell receptors, and other biomolecules (this review is confined to proteins and peptides since the material is too vast).

Although the nanoparticles' interfering with cells' living activity is generally regarded as harmful or at best neutral, there is evidence for their possible useful effect. For example, the data on the effect of nanoparticles on protein fibrillogenesis (which is a pathogenetic mechanism of neurodegenerative disorders, such as Alzheimer's disease) are ambiguous: it is not improbable that, under certain conditions, nanoparticles could inhibit rather than accelerate this process.

Contact:

Prof. Igor R. Nabiev, PhD, DSc, leading scientist of LNBE (igor.nabiev@gmail.com)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

http://www.lnbe.mephi.ru/en

 

 

 
 
 
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