Laboratory of Nano-Bioengineering studying mechanisms of antitumor drug interaction with blood proteins: Publication in the Biochimie

The top-rated journal Biochimie has published a joint study from the Laboratory of Nano-Bioengineering of NRNU MEPhI, Department of Clinical Immunology and Allergology of Sechenov First Moscow State Medical University, and several French and Canadian research centers that deals with the interaction of the Rad51 enzyme inhibitor with blood proteins (Velic, D., Charlier, C., Popova, M., Jaunet-Lahary, T., Bouchouireb, Z., Henry, S., Weigel, P., Masson, J.-Y., Laurent, A., Nabiev, I., Fleury, F. Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches).

The trans-stilbene derivative DIDS, a regulator of anion transport across biological membranes, inhibits the Rad51 enzyme, which is involved in DNA break repair and largely determines the radio- and chemoresistances of cancer cells. The possibility of using DIDS in anticancer therapy depends on its stability and the mechanisms of its interaction with blood proteins.

The authors of the published study analyzed the mechanisms of interaction of DIDS with human serum albumin, a protein accounting for more than half of the serum protein content. DIDS binding sites on the albumin molecule were identified, the binding kinetics was studied, and the binding stoichiometry was established. It was found how the DIDS interactions determine the ratio between its free and bound forms in the blood and, hence, the efficiency of its transport and its resultant efficacy as an antitumor drug.

The Biochimie, a journal published by y Elsevier on behalf of the French Society of Biochemistry and Molecular Biology, is one of the oldest and leading international journals in this field, included in the first quartile (Q1) of medical journals in the SCImago ranking for twenty years in a row.

Contact:

Maria G. Korenkova, director of external relations (MGKorenkova@mephi.ru)

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

http://www.lnbe.mephi.ru/en

 
 
 
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