Four papers from the Laboratory of Nano-Bioengineering (LNBE) and Laboratory of Hybrid Photonic Nanomaterials (LPNM) published in the Proceedings of SPIE

The latest issue of the Proceedings of SPIE, a periodical of the International Society for Optics and Photonics, published four papers from LNBE and LPNM of NRNU MEPhI. These are extended versions of the presentations at the IV International Conference on Applications of Optics and Photonics (AOP 2019) organized by the International Society for Optics and Photonics in Lisbon, Portugal, in late May to early June this year.

Two of these papers present the results of researches in the effect of light–matter coupling and plasmon–exciton interaction, which are supported by the "mega grant" from the RF Ministry of Science and Higher Education (grant no. 14.Y26.31.0011).

The study Polariton-assisted emission of strongly coupled organic dye excitons in a tunable optical microcavity by D. Dovzhenko, K. Mochalov, I. Vaskan, I. Kryukova, Yu. Rakovich, and I. Nabiev demonstrated that light–matter interaction in the strong coupling regime can be controlled by means of a tunable Fabry–Perot microcavity, which was shown in experiments with the organic dye Rhodamine 6G. The results have implications for the development of novel light sources, as well as biosensing and control of chemical reactions.

The study Modification of multiphoton emission properties of single quantum dot due to the long-range coupling with plasmon nanoparticles in thin-film hybrid material by V. Krivenkov, P. Samokhvalov, A Sanchez-Iglesias, M. Grzelczak, I. Nabiev, and Yu. Rakovich dealt with the enhancement of two-photon emission of quantum dots due to their interaction with gold nanorods, which depends on the distance between the excitonic and plasmonic nanoparticles. The mechanisms of this phenomenon have been studied, and the possibility of controlling the degree of luminescence enhancement has been shown. This possibility offers opportunities for the development of novel materials in various fields of optoelectronics and quantum technologies.

The other two papers concern the nano-bioengineering approaches to the diagnosis and treatment of malignant tumors. The studies presented in them have been carried out under State Contract no. 16.1034.2017/PCh.

The subject of the paper Nanophotonic tools based on the conjugates of nanoparticles with the single-domain antibodies for multi-photon micrometastases detection and ultrasensitive biochemical assays by A. Sukhanova, F. Ramos-Gomes, P. Chames, D. Baty, F. Alves, P. Samokhvalov, and I. Nabiev is the application of the nanoprobes consisting of quantum dots and single-domain antibodies that were earlier designed in LNBE to diagnosis and therapy of cancer. Experimental data reported by the authors demonstrate the advantage of two-photon excitation of the nanoprobe photoluminescence, which improves the sensitivity of the method and allows the imagine of cancer markers and, hence, detect newly formed metastases deep in tissues.

The paper Engineering of fluorescent biomaging tools for cancer cell targeting based on polyelectrolyte microcapsules encoded with quantum dots by G. Nifontova, M. Baryshnikova, F. Ramos-Gomes, F. Alves, I. Nabiev, and A. Sukhanova deals with another cancer theranostic tool developed in LNBE, polymer microcapsules optically encoded with quantum dots (in this case, capture antibodies are attached to the microcapsule surface). In particular, these microcapsules are potentially suitable for targeted delivery of antitumor drugs, which can be placed into the cavity of the capsule. The paper describes the procedure for fabrication and encoding of the microcapsules and reports the experimental data that confirm reliable detection of cancer cells using the new tool for delivery and bioimaging.

Practical implementation of these developments will substantially enhance the effectiveness of early diagnosis and treatment of malignant tumors.

References to the papers are given in the lists of publications at the websites of LNBE and LPNM.

Contacts:

Maria G. Korenkova, director of public relations, LNBE (MGKorenkova@mephi.ru)

Alexandra V. Razgulina, engineer, LPNM (alexandrav.korenkova@gmail.com)

Dmitry S. Dovzhenko, Ph.D., researcher (dovzhenkods@gmail.com)

Viktor A. Krivenkov, Ph.D., researcher (vkrivenkov@list.ru)

Galina O. Nifontova, Ph.D., senior researcher (galya.nif@yandex.ru)

Laboratory of Nano-Bioengineering (LNBE), http://lnbe.mephi.ru/en/about and
Laboratory of Hybrid Photonic Nanomaterials (LPNM), http://lpnm.mephi.ru/index.php/en/
National Research Nuclear University MEPhI,
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

 
 
 
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