Researchers from Laboratory of Nano-Bioengineering, NRNU MEPhI, got patent on method for synthesis of quantum dots with multilayered inorganic shell

Rospatent, the RF Federal Intellectual Property Service, has informed on issuing the patent on A Method of Colloidal Synthesis of Core/Multilayered Shell Quantum Dots described in patent application no. 2018135926, an invention by two researchers from the Laboratory of Nano-Bioengineering (LNBE) of NRNU MEPhI, Pavel Samokhvalov, Ph.D., and Pavel Linkov, Doctor of the University of Reims Champagne-Ardenne. The invention was made in the framework of the project on Integrated Computational Engineering, Characterization and Validation of Semiconductor Colloidal Nanocrystals with Advanced Properties (Agreement no. 14.587.21.0039 of July 17, 2017, project RFMEFI58717X0039).

Today quantum dots (QDs) are used in matrices for TV sets, solar batteries, photoelectric cells, and laser diodes, are added to ink for protection of documents, and serve as fluorescent labels in biological imaging systems and medical diagnostic test systems. The QDs used in biological and medical studies should have high colloidal and optical stabilities and should effectively bind biological capture molecules.

Most current methods of synthesis cannot provide sufficiently homogeneous QDs with a high quantum yield and strong colloidal stability in biological fluids, which restricts their use. The patented method yields ensembles of QDs with an epitaxial multilayered shell grown onto their cores which have a quantum yield of no less than 90%, their optical parameters and physical sizes varying within 10%. These QDs retain their luminescent properties for at least a year and stability in biological media for at least six months. In the course of synthesis ligands are immobilized on the shell surface which effectively bind biological capture molecules and shield the core from external factors. This makes them suitable components of highly sensitive advanced biomedical diagnostic test systems.


Pavel A. Linkov, Ph.D., junior researcher (

Maria G. Korenkova, director of external relations (

Laboratory of Nano-Bioengineering (LNBE), Moscow Engineering Physics Institute
31 Kashirskoe shosse, 115409 Moscow, Russian Federation

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