An LNBE project wins the competition for state contract in the field of "Development of the Basis of Biosensor Technologies for Laboratory an Express Diagnostics"

where it scored the highest among 32 projects presented in the framework of the Federal Target Program "Research and Development in Priority Fields of the Science and Technology Complex of Russia for the 2007–2013."

In the framework of the Federal Target Program "Research and Development in Priority Fields of the Science and Technology Complex of Russia for the 2007–2013," a competition has been held for the right to sign a state contract on research in the field of "Task-Oriented Exploratory Research and Laying the Groundwork for Future Science and Technologies in Live Systems" (Item 1.2 of the program, Step II). The results of the competition were announced on February 28. LNBE's project "Approaches to Laboratory and Express Diagnostics Using Biosensors Based on Highly Oriented Conjugates of Single-Domain Antibodies and Fluorescent Nanocrystals" presented by the National Research Nuclear University MEPhI has scored the highest number of points in the competition for Lot no. 2 "Development of the Basis of Biosensor Technologies for Laboratory an Express Diagnostics."

Russian universities; research institutes of the Russian Academy of Sciences, Russian Academy of Medical Sciences, and Ministry of Health; and commercial scientific and production organizations located in various regions of Russia presented projects of novel diagnostic technologies, systems, and instruments. All of them were based on innovative approaches to diagnoses of various diseases, and most of them employed nanotechnologies. LNBE's project was no exception in this respect.

The development of diagnostic nanoprobes based on single-domain antibodies arranged in a controllable way on the surface of fluorescent semiconductor nanocrystals or quantum dots has been one of the main lines of research in LNBE since its foundation. During the past year Dr. Sukhanova, Dr. Oleinikov, and Dr. Artemyev, the leading researchers/heads of the Nanomedicine, Biophysics, and Nanochemistry groups, and Prof. Nabiev, the leading scientist, in collaboration with their French colleagues, have published four studies on the subject, including a detailed protocol for engineering the novel nanoprobes. The results obtained to date have already demonstrated that these nanocrystal–antibody conjugates have a number of advantages over the currently used probes of this type. In particular, the small size of the novel nanoprobes allows them to better penetrate across blood–tissue barriers; the probes more efficiently and specifically bind with the target cells due to the optimal arrangement of antibodies on the nanoparticle surface. This approach is likely to be used not only for early diagnosis, but also for treating tumors. The high appraisal of the project by the Competition Committee of the Ministry of Education and Science of the Russian Federation and signing of the state contract further confirm that ongoing research in this field is socially significant. We hope that its results will be implemented in clinical practice in the near future.

The project proposals were evaluated according to several criteria, the main one being the quality of research and expertise of the competitors (including the characteristics of the intended product, research skills of the project team, experience in the given research area, and pre-existing groundwork). Experts rated the proposals on a point-scale basis according to each criterion, after which three projects with the highest scores were selected. LNBE's project presented by the National Research Nuclear University MEPhI has scored the highest number of points. The other two winners are Lomonosov Moscow State University, Moscow, and Kant Baltic Federal University, Kaliningrad.

Contact:

Prof. Igor Nabiev, PhD, DSc (igor.nabiev@gmail.com),

Leading Scientist of the Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute, 31 Kashirskoe shosse, 115409 Moscow, Russian Federation
http://www.lnbe.mephi.ru

 
 
 
© 2012 Laboratory of Nano-BioEngineering